Ms Huffington, who urges her own staff not to answer work calls outside of working hours, said problems with stress and anxiety could be resolved by changing lifestyles at work.
Speaking to an audience of around 200 people at Bafta's headquarters in London, Ms Huffington said she had taken "the worst decisions" in her life when she was exhausted.
"The nature of the workplace needs to change much faster than it is changing now," she added.
She said as more people now experienced stress, anxiety and depression, prescriptions for antidepressants in the UK had increased by 495 per cent since 1991.
Ms Huffington, the former wife of US Republican politician Michael Huffington, urges her staff not to respond to work emails after normal working hours and recommends removing mobile telephones and computers from bedrooms. She said meditation rooms had also been introduced in the offices of online newspaper, the Huffington Post.
She started her campaign after she broke her cheekbone when she fainted from exhaustion after working excessive hours in 2007.
"There are very simple tricks and techniques, including not charging our phones by our bed, which tempts us in the middle of the night to check our data," Ms Huffington added.
"Whether they are introducing sleeping pods or no email over the weekend, more and more companies now are changing their expectations from their employees."
Ms Huffington, who sold the Huffington Post to AOL in 2005 for a reported £200 million, promoted the Third Metric theory at a conference in New York before she arrived in the UK.
The theory suggests the formula for success in life goes beyond money and power and includes well-being and wisdom.
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